MRC Holland

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Assays for CNV confidence. Learn more at!


MRC Holland is a biotechnology company specialised in the production of assays for gene copy number and gene variant detection. MRC Holland is best known as the producer of Multiplex Ligation-dependent Probe Amplification (MLPA®) assays. MLPA continues to be the gold standard in the field of gene copy number detection, and MRC Holland’s >350 different MLPA assays are used on millions of samples every year. Learn more about MLPA

MRC Holland continues to innovate with the continued development and improvement of MLPA assays, the recent introduction of the Melt Assay for spinal muscular atrophy (SMA) newborn screening, and the impending launch of digitalMLPA. Learn more about our Melt Assays!

It is MRC Holland’s mission to manufacture and distribute affordable and reliable genetic tests worldwide. The company’s products are easy to use and implement into research and diagnostic settings, as they run on standard laboratory equipment, use standard platforms and free MRC Holland-developed software for analysis. To learn more, visit