New Advancements and Trends in Cardiogenomics
21 Mar 2025
Clinical Genetics and Therapeutics
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Accredited:
- Accredited
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Primary Categories:
- Clinical- Pediatric
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Secondary Categories:
- Clinical- Pediatric
This session will provide a contemporary and comprehensive update on how genomic and precision medicine are being utilized in cardiology. A diverse group of faculty will address current state-of-the-art phenotyping, new diagnostic tools, 'gene-first' screening strategies and impact on lives saved, balanced critiques of the pros and cons of such strategies, evidence for surveillance, with a discussion of financial implications for policymakers and stakeholders. Lastly, gene-based therapies as a pathway to prevention and cure will be addressed. The disease spectrum will include myocardial infarction, dyslipidemia, cardiomyopathies, and sudden death.
Learning Objectives
- Evaluate the of a gene-first methodology in investigating the prevalence and penetrance of CDC Tier 1 conditions
- Critique gene-first screening, gene-disease mechanisms, and penetrance in cardiomyopathies (including ACMG-94)
- Apply Polygenic risk scores in preventing Atherosclerotic Cardiovascular Disease and Myocardial Infarction
- Illustrate resolution of variants of uncertain significance in known cardiomyopathy genes
- Summarize current gene editing and gene-based therapies to treat and prevent Mendelian cardiovascular disease
Agenda
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Welcome and Introduction8:00 AM – 8:03 AM -
CDC Tier 1 Screening and The Case for Population-Based Screening8:03 AM – 8:18 AM -
Cardiomyopathy Gene-First Screening and Emerging Knowledge Regarding Frequency and Penetrance8:18 AM – 8:33 AM -
Long Term Follow-up of a Cohort Receiving Polygenic Risk Scores (PRS) for Atherosclerotic Cardiovascular Disease. Can PRS Improve Outcomes?8:33 AM – 8:48 AM -
Emerging Precision and Gene-Based Therapies as a Pathway to Prevention and Cure in Pediatric and Adult Cardiology8:48 AM – 9:03 AM -
Variant Effect Mapping and Mutational Scanning Approaches to Eliminating the Variant of Uncertain Significance in Known Cardiac-Related Genes9:03 AM – 9:18 AM -
Panel DiscussionPanel Discussion and Q&A9:18 AM – 9:30 AM
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