
Andrew Glazer
Assistant Professor of Medicine,
Vanderbilt University Medical Center
I am a geneticist interested in deciphering which mutations underlie rare Mendelian diseases, with a focus on arrhythmia syndromes. I received a B.S. from MIT in molecular biology and a Ph.D. from the University of California-Berkeley in evolutionary genetics and genomics. During my K99-funded postdoctoral fellowship at Vanderbilt University Medical Center, I developed high-throughput methods for studying cardiac ion channels and used biobank genetics to study candidate disease-causing variants. In 2021, I became a tenure-track Assistant Professor at Vanderbilt University Medical Center and started my own lab. I am especially interested in the challenge of deciphering the thousands of rare Variants of Unknown Significance (VUS) that exist in Mendelian disease genes. To improve the accuracy and scope of genomic medicine, the field must develop efficient, scalable methods for identifying variant associations with disease and testing these variants in vitro. I have a particular interest in cell-surface transmembrane proteins, and arrhythmia-associated ion channels in particular. My work developing novel high-throughput methods using automated patch clamping, deep mutational scans, and curating biobank and patient datasets has resulted in the identification of many novel disease-associated variants. Overall, my work has the potential to identify many new disease-causing variants and improve the scope and impact of genetic testing. My goal is to continue to grow my independent lab studying arrhythmia genetics, ion channel proteins, and genomic medicine.
Sessions
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21-Mar-2025