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Bharatendu Chandra

Bharatendu Chandra

Assistant Professor, University of Iowa
I am a neurogeneticist, currently appointed as an Assistant Professor in Medical Genetics and Genomics (Department of Pediatrics) at the University of Iowa. My research focuses on understanding complex neurogenetic and rare disorders using deep phenotyping, genomics tools, bioinformatics, and iPSC-based disease modeling. My long-term goal is to understand the molecular pathophysiology of neurodegenerative disorders and develop precision therapeutics, especially those with early-onset disease presentation. I have over eight years of clinical experience in internal medicine and neurology that has equipped me with the expertise to study the natural history of a variety of neurodegenerative disorders. I study monogenic forms of complex neurological diseases using genomics tools to dissect shared molecular pathomechanisms such as mitochondrial dysfunction and oxidative stress in neurodegeneration. My laboratory currently focuses on functional characterization of neurodegenerative disorders using a multiomics-based approach and human-induced pluripotent stem cell-based ex-vivo disease modeling, including cerebral organoid models. The key premise of my research approach is that a combined multiomics analysis will lead to a better understanding of genetic and phenotypic heterogeneity in rare and complex neurological diseases. We are leveraging the UI rare disease biorepository and UK Biobank data for our translational research.