Melissa J. Landrum PhD is a Staff Scientist at the National Center for Biotechnology Information, within the National Library of Medicine at the National Institutes of Health. She is the team lead for ClinVar, NCBI's archive of human genetic variants and their relationship to disease (www.ncbi.nlm.nih.gov/clinvar/). She establishes the policies, roadmap, and priorities for ClinVar, and she oversees development and operations for the database. Dr. Landrum also serves as a non-voting member of the Steering Committee for the Clinical Genome Resource (ClinGen). Prior to her work on ClinVar, she was a curator for NCBI's RefSeq (www.ncbi.nlm.nih.gov/refseq/) collection. Dr. Landrum received her PhD in human genetics from Johns Hopkins University, where she studied adeno-associated virus as a vector for gene therapy.