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Robert Kueffner

Robert Kueffner

Director for clinical genomics, GeneDx
Robert Küffner is a director for clinical genomics at GeneDX since 2017. Here, he is a member of the R&D team developing new technologies and algorithms to increase the diagnostic yield of genetic tests and managing academic collaborations centered around disease gene discovery. Previously he worked as group leader and lecturer at various academic institutions in Germany such as the Helmholtz Zentrum München (2014-2016) as well as the Ludwig-Maximilians Universität München (2003-2014). Between 2000 and 2003, he was head of software development at the National Center for Genome Resources (NCGR) in New Mexico, USA. He received his PhD in molecular biology in 1998 and habilitated in informatics in 2010.

Küffner's main interests include integrating and deriving insights from a combination of human genetics/genomics/mRNA data as well as clinical trial data or medical records in both rare monogenetic and complex diseases (oncology, CNS, CV). Here, he has been developing novel methods in machine learning, artificial intelligence, data mining, natural language processing as well as statistics. Approaches and tools resulting from this research have been applied in many projects to provide systematic bioinformatics support; e.g. for the pre-processing, analysis and integration of large-scale transcriptomics and proteomics datasets.