Brittany Simpson, MD is an Assistant Professor and Clinical Geneticist at Le Bonheur Children's Hospital and University of Tennessee Health Science Center as well as Clinical Investigator in Neurogenetics at St. Jude Children's Research Hospital's Center for Experimental Neurotherapeutics. Dr. Simpson spends the majority of her time caring for patients with rare genetic conditions with a focus on Congenital Chromatin Disorders, such as Kabuki syndrome, Rubinstein Taybi Syndrome, and Menke Hennekam Syndrome. She participates in care along the lifespan through general genetics outpatient and consultation services at Le Bonheur Children's Hospital and surrounding facilities and is involved in trainee education. She also directs the Chromatin Clinic at St. Jude Children's Research Hospital, which will enroll individuals with chromatin conditions. Dr. Simpson sees individuals and families with these complex disorders to provide holistic, disease-driven care through available information on disease pathology as well as to characterize natural history. Through these endeavors, she is striving to add more information to our knowledge of these conditions to understand what challenges patients face throughout the lifespan, to improve patient outcomes and to accelerate clinical trial development.

A Mississippi native, Dr. Simpson graduated from the University of Mississippi Medical Center in 2016 and completed her combined residency in Pediatrics and Medical Genetics at Cincinnati Children's Hospital Medical Center in 2020 and also served as chief resident from 2019 – 2020. She joined the faculty at Cincinnati Children's Hospital Medical Center from 2020 – 2024 where she served as the director and co-founder of the Epigenetic Syndromes Clinic and natural history study, the Principal Investigator (PI) of the CHARGE Center patient registry, and clinic co-director and lead physician of the Neurofibromatosis Program and PI of the Neurofibromatosis and related disorder natural history study.